This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Uitto, V.-J. Articles by Raeste, A.-M. Search for Related Content PubMed PubMed Citation Articles by Uitto, V.-J. Articles by Raeste, A.-M. Social Bookmarking                         What's this?

Activation of Latent Collagenase of Human Leukocytes and Gingival Fluid by Bacterial Plaque

Department of Medical Chemistry and Institute of Dentistry, Department of Periodontology, University of Helsinki, 00170 Helsinki 17. Finland

Anna-Maija Raeste

Department of Medical Chemistry and Institute of Dentistry, Department of Periodontology, University of Helsinki, 00170 Helsinki 17. Finland

Collagenase activity was studied in human leukocytes, gingival crevicular fluid and bacterial plaque, with soluble radioactive collagen as substrate. Inflamed gingiva liberated vertebrate type collagenase into the crevicular fluid in active form. Healthy gingiva, in contrast, released collagenase in a latent form that could be activated by trypsin or plaque. Plaque also stimulated leukocytes to release collagenase, and activated the latent enzyme.

Journal of Dental Research, Vol. 57, No. 7, 844-851 (1978)
DOI: 10.1177/00220345780570071401


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. Romanelli, S. Mancini, C. Laschinger, C. M. Overall, J. Sodek, and C. A. G. McCulloch Activation of Neutrophil Collagenase in Periodontitis Infect. Immun., May 1, 1999; 67(5): 2319 - 2326. [Abstract] [Full Text] [PDF]

				N.S. Ramamurthy, K.L. Schroeder, T.F. McNamara, A.J. Gwinnett, R.T. Evans, C. Bosko, and L.M. Golub Root-Surface Caries in Rats and Humans: Inhibition by a Non-Antimicrobial Property of Tetracyclines Advances in Dental Research, November 1, 1998; 12(1): 43 - 50. [Abstract] [PDF]

				J.J. Reynolds, R.M. Hembry, and M.C. Meikle Connective Tissue Degradation in Health and Periodontal Disease and the Roles of Matrix Metalloproteinases and Their Natural Inhibitors Advances in Dental Research, July 1, 1994; 8(2): 312 - 319. [Abstract] [PDF]

				L. M. Golub, N.S. Ramamurthy, T. F. McNamara, R. A. Greenwald, and B. R. Rifkin Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs Critical Reviews in Oral Biology & Medicine, January 1, 1991; 2(3): 297 - 321. [Abstract] [Full Text] [PDF]

				D.A. Eisenhauer, R. Hutchinson, T. Javed, and J.K. McDonald Identification of a Cathepsin B-like Protease in the Crevicular Fluid of Gingivitis Patients Journal of Dental Research, August 1, 1983; 62(8): 917 - 921. [Abstract] [PDF]

				L. M. Golub, R. Kaplan, J. E. Mulvihill, and N.S. Ramamurthy Collagenolytic Activity of Crevicular Fluid and of Adjacent Gingival Tissue Journal of Dental Research, November 1, 1979; 58(11): 2132 - 2136. [Abstract] [PDF]