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Journal of Dental Research
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Effect of Progestins on Androgen {Delta}4-3-Ketosteroid-5{alpha}-A-Ring Reductase System in Rat Oral Mucosa

J. Vittek

Department of Medicine, Department of Dentistry, Department of Anatomy, New York Medical College, New York, NY 10029, USA

K. Altman

Department of Medicine, Department of Dentistry, Department of Anatomy, New York Medical College, New York, NY 10029, USA

S.C. Rappaport

Department of Medicine, Department of Dentistry, Department of Anatomy, New York Medical College, New York, NY 10029, USA

G.G. Gordon

Department of Medicine, Department of Dentistry, Department of Anatomy, New York Medical College, New York, NY 10029, USA

J. Hagedorn

Department of Medicine, Department of Dentistry, Department of Anatomy, New York Medical College, New York, NY 10029, USA

A.L. Southren

Department of Medicine, Department of Dentistry, Department of Anatomy, New York Medical College, New York, NY 10029, USA

Rat oral mucosa microsomal {Delta} 4-3-ketosteroid-5{alpha}-A-ring reductase enzyme system, reducing testosterone and 4-androstenedione, was found to be inducible by systemic administration of medroxyprogesterone acetate (MPA). MPA, when used in a mixture with testosterone and/ or 4-androstenedione in vitro, acted as a competitive inhibitor of the reduction of these substrates.

Journal of Dental Research, Vol. 57, No. 3, 511-519 (1978)
DOI: 10.1177/00220345780570032001
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J. Vittek, S.C. Rappaport, G.G. Gordon, J. Hagedoorn, and A.L. Southren
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J. Vittek, G. G. Gordon, S. C. Rappaport, and A. L. Southren
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J. Vittek, G. G. Gordon, S. C. Rappaport, and A. L. Southren
Cellular Regulation of the Metabolism of Androgens in Rat Oral Mucosa. III. Activation of {Delta}4-3-ketosteroid-5{alpha}-A Ring Reductase Enzyme System by 5,5-Diphenylhydantoin
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J. Vittek, S. C. Rappaport, G. G. Gordon, and A. L. Southren
Cellular Regulation of the Metabolism of Androgens in Rat Oral Mucosa: I. Effect of Medroxyprogesterone Acetate (MPA) on the Soluble Supernatant (Cytosol) Activating Microsomal {Delta}4-3-Ketosteroid-5{alpha}-Reductase and 17{beta} -Hydroxysteroid Oxidoreductase Enzyme Systems
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