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Journal of Dental Research
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The Effect of Eugenol on Oral Mucous Membranes

George Kozam

College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103

Gary M. Mantell

College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103

Eugenol, in the 100 percent concentration in commercial use, was applied to a circumscribed area, 3 mm in diameter, of rat labial mucosa for 1 minute. Reaction periods of 15 minutes, 1, 2, 4 and 6 hours were then permitted. Using routine histological procedures for processing the experimental tissues, it was observed that eugenol caused denaturation of cytoplasmic proteins and loss of staining capacity of epithelium, loss of cell boundaries, swelling and cell necrosis. In addition, vesicle formation, edema in the corium, and striated muscle dissolution were observed.

Journal of Dental Research, Vol. 57, No. 11, 954-957 (1978)
DOI: 10.1177/00220345780570110901
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