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Alterations in Lactoferrin in Salivary Gland Disease

Division of Preventive Dentistry and Division of Oral Surgery, School of Dental and Oral Surgery, Columbia University, 630 West 168th Street, New York, N.Y. 10032, USA

Irwin D. Mandel

Division of Preventive Dentistry and Division of Oral Surgery, School of Dental and Oral Surgery, Columbia University, 630 West 168th Street, New York, N.Y. 10032, USA

Daniel Karlan

Division of Preventive Dentistry and Division of Oral Surgery, School of Dental and Oral Surgery, Columbia University, 630 West 168th Street, New York, N.Y. 10032, USA

Harold Baurmash

Division of Preventive Dentistry and Division of Oral Surgery, School of Dental and Oral Surgery, Columbia University, 630 West 168th Street, New York, N.Y. 10032, USA

During the active phase of chronic recurrent parotitis there is a marked elevation in the parotid concentration of lactoferrin (Lf), an iron-binding glycoprotein with antibacterial properties. The Lf concentration decreases during the recovery period, but still remains above normal levels. The changes of Lf in parotitis parallel recent findings in mastitis and pancreatitis. Elevations in Lf were also noted in five of six subjects with Sjögren's disease, but not in subjects with sarcoidosis, diabetes or "dry mouth" without sialographic changes. The source of the Lf has not been determined; it could arise in part from disrupting polymorphonuclear leucocytes and in part from epithelial cells that synthesize Lf in the salivary glands. Inflammatory stimulation of Lf synthesis would suggest a basic protective mechanism in exocrine glands and should be fully explored.

Journal of Dental Research, Vol. 57, No. 1, 43-47 (1978)
DOI: 10.1177/00220345780570011801


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