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Journal of Dental Research
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Collaborative Evaluation of a Rat Caries Model in Six Laboratories

R.H. Larson

National Institute of Health, Room 528, Westwood Bldg., Bethesda, Maryland 20014

S.M. Amsbaugh

National Institute of Health, Room 528, Westwood Bldg., Bethesda, Maryland 20014

J.M. Navia

University of Alabama, Birmingham, Alabama 35233

S. Rosen

Ohio State University, College of Dentistry, Columbus, Ohio 43210

G.S. Schuster

Medical College of Georgia, Augusta, Georgia 30902

J.H. Shaw

Harvard School of Medicine, Boston, Massachusetts 02115, USA

When highly controlled parallel rat caries studies were run simultaneously in six laboratories, a similar pattern of caries developed in every laboratory with a range in mean values such that the results of no investigator were significantly different from those of at least two others. These results indicate that the major factors influencing development of rat caries have been recognized and can be controlled within reasonable limits.

Journal of Dental Research, Vol. 56, No. 8, 1007-1012 (1977)
DOI: 10.1177/00220345770560080201
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This article has been cited by other articles:


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A.R. Firestone, F.F. Feagin, C.N. Graves, G.K. Stookey, C. Rodlun, and J. Warrick
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A.R. Firestone and J.M. Navia
In vivo Measurements of Sulcal Plaque pH in Rats After Topical Applications of Xylitol, Sorbitol, Glucose, Sucrose, and Sucrose Plus 53 mM Sodium Fluoride
Journal of Dental Research, January 1, 1986; 65(1): 44 - 48.
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G.S. Schuster, J.M. Navia, S. Amsbaugh, and R.H. Larson
Sources of Variability in Rat Caries Studies: Microbial Infection and Caging Procedure
Journal of Dental Research, February 1, 1978; 57(2): 355 - 360.
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