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Journal of Dental Research
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Blood and Urinary 18F Pharmaco kinetics Following Parenteral Administration in the Rat

Gary M. Whitford

Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA

Jimmy R. Patten

Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA

Keith E. Reynolds

Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA

David H. Pashley

Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA

Blood and urinary excretion time courses of 18F administered parenterally to rats were monitored for two hours. The intraperitoneal, subcutaneous, and intravenous routes gave kinetically indistinguishable results after ten minutes following the dose. The blood time course during the first hour following intramuscular dosing showed a relative constancy and suggested a delayed absorption time.

Journal of Dental Research, Vol. 56, No. 7, 858-861 (1977)
DOI: 10.1177/00220345770560072301
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G. M. Whitford, J. Ekstrand, R. S. Callan, and D. E. Pearson
Subcutaneously Implanted Alginate as a Continuous-release Source of Fluoride
Journal of Dental Research, February 1, 1980; 59(2): 186 - 191.
[Abstract] [PDF]