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Journal of Dental Research
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Collagenolysis by Human Gingival Fibroblast Cell Lines

George G. Rose

Departments of Internal Medicine and Periodontics, The University of Texas Health Science Center, Dental Branch, Houston, Texas 77030, USA

Paul B. Robertson

Departments of Internal Medicine and Periodontics, The University of Texas Health Science Center, Dental Branch, Houston, Texas 77030, USA

Human gingival fibroblast cell lines were initiated in flask cultures from four periodontal patients with the diagnoses of periodontitis (two patients), fibromatosis, and Dilantin hyperplasia. The collagenolytic propensity of these fibroblasts cultivated on collagen-coated cover slips and the inhibitory effect of serum were evaluated by direct microscopic observations.

Journal of Dental Research, Vol. 56, No. 4, 416-424 (1977)
DOI: 10.1177/00220345770560040901
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