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Reduction of Dental Decay in Rampant Caries Individuals Following Short-Term Kanamycin Treatment

Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109, USA

D.R. Bradbury

Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109, USA

M.P. Woolfolk

Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109, USA

A week of kanamycin gel treatment before and after the placement of dental restorations, compared to a placebo gel treatment, significantly reduced the levels of cultivable bacteria, S mutans and S sanguis, in the plaque samples collected immediately after the completion of the gel treatments, and was associated with a 46% reduction in new carious surfaces in the 14- to 37-month period following the gel treatment.

Journal of Dental Research, Vol. 56, No. 3, 254-265 (1977)
DOI: 10.1177/00220345770560031101


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