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Journal of Dental Research
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*DOPAMINE
*LIDOCAINE
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Lidocaine's Influence on the Accumulation and Depletion Rates of Mouse Brain Amines

Alfred E. Ciarlone

Department of Pharmacology-Physiology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA

James W. Smudski

Department of Pharmacology-Physiology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA

Mouse brain was analyzed for serotonin, norepinephrine, and dopamine. Pargyline plus lidocaine treatment caused an increased accumulation rate of serotonin over one hour compared to pargyline controls. {alpha} Methyl-p-tyrosine plus lidocaine treatment caused a decreased depletion rate of dopamine over four hours compared to rates of {alpha} methyl-p-tyrosine controls, and no difference for norepinephrine.

Journal of Dental Research, Vol. 56, No. 11, 1391-1394 (1977)
DOI: 10.1177/00220345770560111901
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This article has been cited by other articles:


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A.E. Ciarlone and M.S. Juras
Lidocaine and Procaine Alter Rat Brain Amines
Journal of Dental Research, November 1, 1981; 60(11): 1886 - 1890.
[Abstract] [PDF]

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 JDRHome page
A. E. Ciarlone
Alteration of Lidocaine- or Procaine-induced Convulsions by Manipulation of Brain Amines
Journal of Dental Research, February 1, 1981; 60(2): 182 - 186.
[Abstract] [PDF]