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Journal of Dental Research
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Effects of Alexidine·2HCl Mouthwash on Plaque and Gingivitis after six Months

Vladimir W. Spolsky

Section of Preventive Dentistry and Public Health, School of Dentistry; Health Sciences Computer Facility, University of California at Los Angeles, Center for the Health Sciences, Los Angeles, California 90024, USA

Alan B. Forsythe

Section of Preventive Dentistry and Public Health, School of Dentistry; Health Sciences Computer Facility, University of California at Los Angeles, Center for the Health Sciences, Los Angeles, California 90024, USA

Two-hundred and fourteen subjects ranging in age from 22 to 63 years used either a mouthwash that contained 0.035% w/v alexidine· 2HCl (2-ethylhexyl bisbiguanidine dihydrochloride) or a placebo twice daily on a double-blind basis for six months in conjunction with routine oral hygiene procedures. The results indicated that alexidine·2HCl was safe and was statistically more effective in producing a clinically significant reduction in gingivitis than was the placebo.

Journal of Dental Research, Vol. 56, No. 11, 1349-1358 (1977)
DOI: 10.1177/00220345770560111101
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