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Journal of Dental Research
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Effects of Repeated Ingestion of Large Quantities of Acetylsalicylic Acid on Membranous Bone Growth and Dentin Apposition in Young Monkeys

Peter K-J. Yen

Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA

James H. Shaw

Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA

Four oral doses of acetylsalicylic acid at 325 mg/kg body weight were given to young monkeys that received a series of injections of lead acetate as an intravital stain. Bone growth, including remodeling of the Haversian canal system, was greatly inhibited, whereas dentin apposition was unaffected.

Journal of Dental Research, Vol. 56, No. 10, 1265-1270 (1977)
DOI: 10.1177/00220345770560103101
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T. R. Przybeck, S. Molnar, and B. K. Suarez
A Three-Dimensional Model of Dentin Apposition
Journal of Dental Research, July 1, 1979; 58(7): 1735 - 1739.
[Abstract] [PDF]