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Collagen Biochemistry of the two Layers of Carious Dentin

Departments of Biochemistry and Operative Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo 113, Japan

Kantaro Ohgushi

Departments of Biochemistry and Operative Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo 113, Japan

Takao Fusayama

Departments of Biochemistry and Operative Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo 113, Japan

Carious dentin consists of a superficial first layer and a deeper second layer. Chromatographically compared with sound dentin, the second layer showed a change in the cross-linkage of collagen with cross links partly shifting to precursors. In contrast, the first layer showed virtual disappearance of cross links indicating irreversible denaturation of collagen.

Journal of Dental Research, Vol. 56, No. 10, 1233-1237 (1977)
DOI: 10.1177/00220345770560102301


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