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Journal of Dental Research
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Studies on Hypoxia: XII. Detrimental Effects of Synthetic Polyribonucleotides on Epiphyseal Plates of Rats Exposed to Hypoxia

C.S. Koo

Department of Oral Biology, University of Michigan, Ann Arbor, Michigan 48104, USA

M.K. Kim

Department of Anatomy, University of Michigan, Ann Arbor, Michigan 48104, USA

S.S. Han

Program in Biology of Aging, University of Michigan, Ann Arbor, Michigan 48104, USA

The effect of different doses of polyadenylic and polyuridylic acids (poly A:U) was studied in control rats and in rats exposed to hypoxia. In the control rats, administration of different doses of poly A:U did not change the thickness of the epiphyseal plate or increase the incorporation of 3H-phenylalanine as judged using radioautography. Rats exposed to hypoxia showed a significant dose-related reduction in the thickness of the epiphyseal plate and 3H-phenylalanine incorporation.

Journal of Dental Research, Vol. 55, No. 4, 643-647 (1976)
DOI: 10.1177/00220345760550041701
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