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Journal of Dental Research
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Studies on Hypoxia: XI. Long-Term Effects on the Epiphyseal Plate—A Histomeric and Radioautographic Study

S.S. Han

Departments of Oral Biology and Anatomy, and Program in Biology in Aging, The University of Michigan, Ann Arbor, Michigan 48104, USA

C.S. Koo

Departments of Oral Biology and Anatomy, and Program in Biology in Aging, The University of Michigan, Ann Arbor, Michigan 48104, USA

M.K. Kim

Departments of Oral Biology and Anatomy, and Program in Biology in Aging, The University of Michigan, Ann Arbor, Michigan 48104, USA

Rats were exposed to hypoxia for one week. The mean thickness of epiphyseal plates from control rats was 430 micrometers (µm) which was reduced to 313 µm in hypoxic rats. Radioautographic incorporation of 3H-phenylalanine by connective tissue cells in hypoxic rats was reduced up to 38% in control rats.

Journal of Dental Research, Vol. 55, No. 3, 367-371 (1976)
DOI: 10.1177/00220345760550031301
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C.S. Koo, M.K. Kim, and S.S. Han
Studies on Hypoxia: XII. Detrimental Effects of Synthetic Polyribonucleotides on Epiphyseal Plates of Rats Exposed to Hypoxia
Journal of Dental Research, July 1, 1976; 55(4): 643 - 647.
[Abstract] [PDF]