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Journal of Dental Research
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Effect of {alpha}, {alpha}'-Dipyridyl on the Basement Membrane of Tooth Germs In Vitro

Sebastiao Hetem

Department of Oral Biology, School of Dental Medicine, University of Connecticut, Farmington, Connecticut 06032, USA

Edward J. Kollar

Department of Oral Biology, School of Dental Medicine, University of Connecticut, Farmington, Connecticut 06032, USA

Leslie S. Cutler

Department of Oral Biology, School of Dental Medicine, University of Connecticut, Farmington, Connecticut 06032, USA

James A. Yaeger

Department of Oral Biology, School of Dental Medicine, University of Connecticut, Farmington, Connecticut 06032, USA

Dipyridyl inhibits the morphogenesis of tooth germs, but the germs recover when transferred to control medium. In this study, the effect of dipyridyl on basement membrane was investigated in vitro. The basal lamina was always present, but the subjacent collagen fibrils disappeared in the presence of dipyridyl and reappeared during recovery in control medium.

Journal of Dental Research, Vol. 54, No. 4, 783-787 (1975)
DOI: 10.1177/00220345750540041501
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