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Effects of Tetracyclines on Membranous Bone Growth and Dentin Apposition in Young Rhesus Monkeys

Peter K.-J. Yen

Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA

James H. Shaw

Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA

Various tetracyclines were administered by different routes to young monkeys that received multiple injections of lead acetate as an intravital stain of calcification sites. Microscopically, the tetracyclines inhibited membranous bone growth, but they did not affect dentin apposition.

Journal of Dental Research, Vol. 53, No. 4, 897-906 (1974)
DOI: 10.1177/00220345740530042101
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