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Journal of Dental Research
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*Cold Sores
*Menstruation
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Recurrent Herpes Labialis, Recurrent Aphthous Ulcers, and the Menstrual Cycle

Arthur L. Segal

Division of Behavioral Science, Department of Oral Medicine, School of Dental Medicine and the Center for Oral Health Research, University of Pennsylvania, and the Philadelphia General Hospital, Philadelphia, Pennsylvania 19104, USA

Aaron H. Katcher

Division of Behavioral Science, Department of Oral Medicine, School of Dental Medicine and the Center for Oral Health Research, University of Pennsylvania, and the Philadelphia General Hospital, Philadelphia, Pennsylvania 19104, USA

Vernon J. Brightman

Division of Behavioral Science, Department of Oral Medicine, School of Dental Medicine and the Center for Oral Health Research, University of Pennsylvania, and the Philadelphia General Hospital, Philadelphia, Pennsylvania 19104, USA

Michael F. Miller

Division of Behavioral Science, Department of Oral Medicine, School of Dental Medicine and the Center for Oral Health Research, University of Pennsylvania, and the Philadelphia General Hospital, Philadelphia, Pennsylvania 19104, USA

A prospective study of 104 student nurses determined the frequency of recurrent herpes labialis and recurrent aphthous ulcers within the menstrual cycle. Each nurse kept daily calendars recording inter alia menses and episodes of lesions. Episodes of aphthae were not associated with any specific intervals in the menstrual cycle. There was a greater than expected incidence of episodes of herpetic lesions in the eight days preceding the onset of menses.

Journal of Dental Research, Vol. 53, No. 4, 797-803 (1974)
DOI: 10.1177/00220345740530040501
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