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Journal of Dental Research
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Effect of a Topically Applied 3 % Vancomycin Gel on Streptococcus mutans on Different Tooth Surfaces

Harold V. Jordan

Forsyth Dental Center, Boston, Massachusetts 02115, USA

Paul F. De Paola

Forsyth Dental Center, Boston, Massachusetts 02115, USA

A 3% vancomycin gel was applied for ten minutes to the teeth of 10- to 12-year-old children using custom-fitted trays. Treatment was once a day for five consecutive days. Significant suppression of Streptococcus mutans was found in sound and carious fissures one week after treatment, with a decline in the oral hygiene index. Response to treatment was the same in subjects with and without large, open, carious lesions.

Journal of Dental Research, Vol. 53, No. 1, 115-120 (1974)
DOI: 10.1177/00220345740530010301
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