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Temporary Suppression of Streptococcus mutans in Humans through Topical Application of Vancomycin

Forsyth Dental Center, Boston, Massachusetts 02115, USA, Boston University School of Graduate Dentistry, Boston, Massachusetts

Harold V. Jordan

Forsyth Dental Center, Boston, Massachusetts 02115, USA, Boston University School of Graduate Dentistry, Boston, Massachusetts

Joel Berg

Forsyth Dental Center, Boston, Massachusetts 02115, USA, Boston University School of Graduate Dentistry, Boston, Massachusetts

Vancomycin, an antibiotic with desirable properties for oral usage, was applied in a 15% gel formulation to the teeth of children, and as a 1% paste to the teeth of young adults. Temporary suppression was observed in the presence of Streptococcus mutans, an organism which has been implicated in human dental caries.

Journal of Dental Research, Vol. 53, No. 1, 108-114 (1974)
DOI: 10.1177/00220345740530010201


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