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Journal of Dental Research
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Mast Cells and Basophils in the Mandibular Alveolar Connective Tissue and Bone Marrow of Germfree Albino Rats

John E. Wolf

College of Dentistry, The Ohio State University, Columbus, Ohio 43210, USA

George R. App

College of Dentistry, The Ohio State University, Columbus, Ohio 43210, USA

Rudy C. Melfi

College of Dentistry, The Ohio State University, Columbus, Ohio 43210, USA

Mast cells and basophils decreased in numbers in older germfree rats. Degranulation of mast cells increased in older animals. It is possible that aging is related to increasing degranulation and the release of pharmacologically active substances such as heparin. The release of heparin might play a role in bone loss.

Journal of Dental Research, Vol. 52, No. 5, 1092-1096 (1973)
DOI: 10.1177/00220345730520051801
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