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Journal of Dental Research
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Preferential Induction of Rough Variants in Streptococcus mutans by Ethidium Bromide

Masako Higuchi

Tokoku University, School of Dentistry, Sendai, Japan

Kaeko Endo

Tokoku University, School of Dentistry, Sendai, Japan

Etsuro Hoshino

Tokoku University, School of Dentistry, Sendai, Japan

Shimpei Araya

Tokoku University, School of Dentistry, Sendai, Japan

Different colonial variants of Streptococcus mutans were studied. Rough variants were induced frequently from an original mucoid-type strain in cultures to which ethidium bromide was added. Rough variants had less insoluble dextran like polysaccharides than the original mucoid strain. Mitomycin C caused cell lysis in mucoid cells but not in rough cells.

Journal of Dental Research, Vol. 52, No. 5, 1070-1075 (1973)
DOI: 10.1177/00220345730520051401
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