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Journal of Dental Research
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Collagenolysis in Cultured Tissue: I. Digestion of Mesenteric Fibers by Enzymes from Explanted Gingival Tissue

A. Cecil Taylor

The University of Texas Dental Science Institute at Houston, Houston, Texas 77025, USA

Collagen fibers of cultured rat mesentery were lysed by an enzyme diffusing from explants of gingival tissue in the same culture. The enzyme was nondialyzable, heat labile, and specific for collagen. Its action was facilitated by heparin, vitamin A, and a product of mast cell granules but was inhibited by cortisone and histamine. Gingival cells in prolonged culture lost the capacity to digest collagen.

Journal of Dental Research, Vol. 50, No. 5, 1294-1300 (1971)
DOI: 10.1177/00220345710500053501
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This article has been cited by other articles:


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G. G. Rose and P. B. Robertson
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B. B. Kamrin
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A. C. Taylor
Collagenolysis in Cultured Tissue: II. Role of Mast Cells
Journal of Dental Research, September 1, 1971; 50(5): 1301 - 1306.
[Abstract] [PDF]