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Journal of Dental Research
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Autoradiographic Demonstration of DNA Synthesis in Selected Epithelial Tissues in Male Rats

Marshall C. England, JR

School of Dentistry, Medical College of Virginia, Health Sciences Division, Virginia Commonwealth University, Richmond, Virginia 23219

George W. Burke, JR

School of Dentistry, Medical College of Virginia, Health Sciences Division, Virginia Commonwealth University, Richmond, Virginia 23219

Eleven white male rats received intravenous injections of thymidine -3H at a dose rate of 1 µc/gm body weight. The rats were killed at four-hour intervals over a 24-hour period Epithelial specimens from the hard and soft palate, cheek, skin, and tail were subjected to autoradiography. The results confirm prior data from liquid scintillation studies, which showed a maximal DNA synthesis at 4:30 to 8:45 AM and minimal synthesis at 3:40 to 8:30 PM.

Journal of Dental Research, Vol. 48, No. 6, 1219-1223 (1969)
DOI: 10.1177/00220345690480062201
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J.S. Rowat and C.A. Squier
Rates of Epithelial Cell Proliferation in the Oral Mucosa and Skin of the Tamarin Monkey (Saguinus fuscicollis)
Journal of Dental Research, November 1, 1986; 65(11): 1326 - 1331.
[Abstract] [PDF]