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The Origin of Collagenase in Periodontal Tissues of Man

Department of Health, Education, and Welfare, National Institutes of Health, Bethesda, Maryland 20014

William A. Gibson

Department of Health, Education, and Welfare, National Institutes of Health, Bethesda, Maryland 20014

Gerald S. Lazarus

Department of Health, Education, and Welfare, National Institutes of Health, Bethesda, Maryland 20014

Howard A. Bladen

Department of Health, Education, and Welfare, National Institutes of Health, Bethesda, Maryland 20014

Karen A. Whedon

Department of Health, Education, and Welfare, National Institutes of Health, Bethesda, Maryland 20014

Collagenase is produced by both epithelial and connective tissue cells of the human gingiva. Collagenase action was shown through viscometry, acrylamide gel electrophoresis, and electron microscopy. Collagen is cleaved into one-quarter and three-quarter pieces by collagenase derived from human gingiva.

Journal of Dental Research, Vol. 48, No. 5, 646-651 (1969)
DOI: 10.1177/00220345690480050701


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