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Journal of Dental Research
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Acquisition of Fluoride in Vivo by Enamel from Repeated Topical Sodium Fluoride Applications in a Fluoridated Area: A Preliminary Report

James R. Mellberg

Davies, Rose Hoyt Pharmaceutical Division, The Kendall Company, Barrington, Illinois

Clyde R. Nicholson

Central Piedmont Community College, Charlotte, North Carolina

Barry G. Miller

US Department of Health, Education, and Welfare, National Institutes of Health, Bethesda, Maryland

Harold R. Englander

US Public Health Service, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland

Fluoride acquisition by deciduous enamel of 11- to 14-year-old children, living in a fluoridated area, was studied during repeated topical applications of acidulated phosphate fluoride gel drops in plastic mouthpieces. Enamel fluoride progressively increased as the number of treatments increased, reaching a concentration of 1,785 ppm at a depth of 5µ after an average of 56 treatments.

Journal of Dental Research, Vol. 47, No. 5, 733-736 (1968)
DOI: 10.1177/00220345680470051201


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J. R. Mellberg, C. R. Nicholson, B. G. Miller, and H. R. Englander
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