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Journal of Dental Research
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Development of Caries in the Hunt-Hoppert Caries-Susceptible and Caries-Resistant Rats Under Different Experimental Conditions

Rachel H. Larson

US Department of Health, Education, and Welfare, Public Health Service, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland

Paul H. Keyes

US Department of Health, Education, and Welfare, Public Health Service, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland

Bette Joan Goss

US Department of Health, Education, and Welfare, Public Health Service, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland

Rats of both Hunt-Hoppert lines, originally designated as caries-susceptible (Ca-S) and caries-resistant (Ca-R) lines, were highly susceptible to caries when subjected to a combination of diet and microflora that provided a challenge to the resistance of all surfaces of the teeth. Strain differences were indicated by the predominance of sulcal lesions in the Ca-S line and smooth-surface lesions in the Ca-R line.

Journal of Dental Research, Vol. 47, No. 5, 704-709 (1968)
DOI: 10.1177/00220345680470050701
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