Figure 3a. Identification of a C826T (Gln176X) mutation in exon 8 of the ENAM gene. Shown are sequence tracings (left — plus strand, forward; right — minus strand, reverse) obtained for exon 8 of the ENAM gene from a homozygous ATE1 mouse (top) and a C57BL/6 control (bottom). The amino acid sequence derived after translation of the ENAM cDNA is given below the nucleotide sequence. The mutated nucleotide is underlined; ###, translational termination signal.