Figure 4. VEGF production by oral and epidermal keratinocytes. 1 x 105 oral and skin keratinocytes were incubated under hypoxia for 18 hrs. Culture supernatants were collected and analyzed (by ELISA) for VEGF release. As a control, VEGF protein concentrations were determined in media of cells grown under normoxia. The bars represent the mean ± SE (n = 3). **p < 0.01 hypoxia vs. normoxia.