Figure 2. Estrous-cycle-dependent variation in tooth movement. (A) The mean tooth movement after 5 consecutive estrous cycles in the 4 experimental groups. Each column represents the mean ± SEM. The number of animals for each column ranges from 4 to 7. *p < 0.05 by the Tukey-Kramer test. (B) Time course of tooth movement in rats in the Estrus and Pro-estrus groups. Each point represents the mean ± SEM of 4 to 7 animals. p < 0.001 for number of force applications and p < 0.05 for groups by two-way repeated-measures ANOVA. *p < 0.05 vs. the Pro-estrus group by the Tukey-Kramer test.